Later attending the University of Santo Tomas, he soon quit school to fulfill more art assignments for Paraluman magazine, Liwayway, Ace Publications, Gold Star Publishing, and numerous others. Handling magazine and book illustrations, covers, portraits, and movie advertisements, this hard working artist still had time to team up with some of the best talent to produce many new comic series over the years. His success in the art world helped him win awards and serve as as officer in both the prestigious Philippine Illustrators and Cartoonist and the National Press Club. Leaving for the United States in 1969, Western Publications quickly picked up the talented illustrator to draw various sword and sorcery and adventure titles like Davy Crockett, Dagar, Tragg and the Sky Gods, Brothers of the Spear, The Occult Files of Dr. Spektor, and Mystery Comics Digest, just to name a few.
Santos unique style had a loose and rough approach to his heroic characters with both some life-like portrait expressions and realistic but exaggerated and distorted figures, which were a wonderful combination that made him stand out in the comic world. The artist was a member of many groups including the Philippine Comic Archives and the Philippine Science-Fantasy Society. His fine art paintings have been exhibited by the Society of Western Artists, winning numerous awards while shown in international art shows, universities, museums, galleries, and private collections. A man of many talents he is well remembered by fan and pro alike for his contributions to comic art.